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Advances in Pediatrics

Infantile Hypertrophic Pyloric Stenosis: Epidemiology, Genetics, and Clinical Update

  • Judith D. Ranells
    Affiliations
    Department of Pediatrics, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA
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  • Jane D. Carver
    Affiliations
    Department of Pediatrics, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA
    Search for articles by this author
  • Russell S. Kirby
    Correspondence
    Corresponding author. Department of Community and Family Health, College of Public Health, University of South Florida, 13201 Bruce B. Downs Boulevard, MDC56, Tampa, FL 33612.
    Affiliations
    Department of Pediatrics, College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA

    Department of Community and Family Health, College of Public Health, University of South Florida, 13201 Bruce B. Downs Boulevard, MDC56, Tampa, FL 33612, USA
    Search for articles by this author
      Infantile hypertrophic pyloric stenosis (IHPS), the most common surgical condition producing emesis in infancy, was first described by Hirschsprung [
      • Hirschsprung H.
      Falle von angeborener Pylorusstenose, beobachtet bei Sauglingen.
      ] in 1888. Ramstedt performed the first successful pyloromyotomy in 1912; however, most cases were lethal at that time. Although advances in medical knowledge and care have resulted in minimal mortality and morbidity today, the cause of IHPS remains unclear [
      • Aspelund G.
      • Langer J.C.
      Current management of hypertrophic pyloric stenosis.
      ]. This article provides an update on IHPS, focusing on pathogenesis, diagnosis and treatment, descriptive epidemiology and associated risk factors, and current understanding of the role of genetics.
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