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Advances in Pediatrics

The Human Parechoviruses: An Overview

      In the summer of 1956, the first two members of the Parechovirus genus were isolated from Ohio children with diarrhea [
      • Wigand R.
      • Sabin A.B.
      Properties of ECHO types 22, 23 and 24 viruses.
      ]. Human parechoviruses (HPeVs) types 1 and 2, as they would eventually become known, were originally designated as the 22nd and 23rd members (Harris and Williamson strains, respectively) of the “enteric cytopathic human orphan (ECHO) group” or echoviruses (E22 and E23, respectively) [
      Enteric cytopathogenic human orphan (ECHO) viruses.
      ]. Over the next 50 years, the advent of molecular and genomic virology would provide tools for their in-depth characterization and the identification of other members of the Parechovirus genus [
      • Knowles N.J.
      • Hovi T.
      • King A.M.Q.
      • et al.
      Overview of taxonomy.
      ]. This article reviews past and current medical literature concerning the virology, epidemiology, clinical significance, and diagnosis of the HPeV.
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