Adrenocortical tumors are rare in children and usually present with virilization before
age 5 years. They may also present as Cushing syndrome or with mixed effects.
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References
- Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit.Endocr Rev. 2011; 32: 317-355
- Endogenous infection in mice with streptozotocin-induced diabetes. A feature of bacterial translocation.Can J Microbiol. 1984; 30: 1344-1348
- Unusually large mass of carcinomatous deposit in one of the suprarenal capsules of a child.Trans Pathol Soc Lond. 1865; 16: 250
- Differences in the molecular mechanisms of adrenocortical tumorigenesis between children and adults.Mol Cell Endocrinol. 2012; 351: 52-57
- Pediatric adrenocortical tumor - review and management update.Curr Opin Endocrinol Diabetes Obes. 2020; 27: 177-186
- Detailed haplotype analysis at the TP53 locus in p.R337H mutation carriers in the population of Southern Brazil: evidence for a founder effect.Hum Mutat. 2010; 31: 143-150
- Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry.J Clin Oncol. 2004; 22: 838-845
- Adrenocortical carcinoma in children: a clinicopathological analysis of 41 patients at the Mayo Clinic from 1950 to 2017.Horm Res Paediatr. 2018; 90: 8-18
- The optimal imaging of adrenal tumours: a comparison of different methods.Endocr Relat Cancer. 2007; 14: 587-599
- The international pediatric adrenocortical tumor registry initiative: contributions to clinical, biological, and treatment advances in pediatric adrenocortical tumors.Mol Cell Endocrinol. 2012; 351: 37-43
- Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?.Ann Intern Med. 1969; 71: 747-752
- Beyond Li Fraumeni syndrome: clinical characteristics of families with p53 germline mutations.J Clin Oncol. 2009; 27: 1250-1256
- Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors.Am J Hum Genet. 1999; 65: 995-1006
- An inherited mutation outside the highly conserved DNA-binding domain of the p53 tumor suppressor protein in children and adults with sporadic adrenocortical tumors.J Clin Endocrinol Metab. 2001; 86: 4970-4973
- An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma.Proc Natl Acad Sci U S A. 2001; 98: 9330-9335
- Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers.Clin Cancer Res. 2010; 16: 5133-5141
- Wnt signaling in the stem cell niche.Curr Opin Hematol. 2004; 11: 88-94
- Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors.Cancer Res. 2005; 65: 7622-7627
- Molecular genetics of adrenocortical tumor formation and potential pharmacologic targets.Minerva Endocrinol. 2012; 37: 133-139
- Risk of tumorigenesis in overgrowth syndromes: a comprehensive review.Am J Med Genet C Semin Med Genet. 2005; 137C: 53-71
- IGF2 and IGF1R in pediatric adrenocortical tumors: roles in metastasis and steroidogenesis.Endocr Relat Cancer. 2016; 23: 481-493
- Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors.Cancer Res. 2010; 70: 4666-4675
- Genomic landscape of paediatric adrenocortical tumours.Nat Commun. 2015; 6: 6302
- IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer.Endocrine. 2019; 64: 673-684
- Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors.Am J Surg Pathol. 1984; 8: 163-169
- Clinical, hormonal and pathological findings in a comparative study of adrenocortical neoplasms in childhood and adulthood.J Urol. 1995; 154: 2004-2009
- Adrenal cortical neoplasms in the pediatric population: a clinicopathologic and immunophenotypic analysis of 83 patients.Am J Surg Pathol. 2003; 27: 867-881
- Usefulness of Wieneke criteria in assessing morphologic characteristics of adrenocortical tumors in children.Pediatr Surg Int. 2015; 31: 563-571
- Biology, clinical characteristics, and management of adrenocortical tumors in children.Pediatr Blood Cancer. 2005; 45: 265-273
- Adrenal cortical carcinoma.J Urol. 1978; 120: 660-665
- Childhood adrenocortical tumors.J Clin Endocrinol Metab. 1997; 82: 2027-2031
- Diagnosis, treatment and outcome of adrenocortical cancer.Br J Surg. 2015; 102: 291-306
- Impact of lymphadenectomy on the oncologic outcome of patients with adrenocortical carcinoma.Ann Surg. 2012; 255: 363-369
- Role of radiotherapy in adrenocortical carcinoma.Cancer J. 2013; 19: 288-294
- Systemic treatment of adrenocortical carcinoma in children: data from the German GPOH-MET 97 trial.Klin Padiatr. 2012; 224: 366-371
- Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5alpha-reductase, explaining the need for personalized glucocorticoid and androgen replacement.J Clin Endocrinol Metab. 2013; 98: 161-171
- Pediatric adrenocortical tumours.Best Pract Res Clin Endocrinol Metab. 2020; 34: 101448
- A genetic and molecular update on adrenocortical causes of Cushing syndrome.Nat Rev Endocrinol. 2016; 12: 255-262
- Carney complex and other conditions associated with micronodular adrenal hyperplasias.Best Pract Res Clin Endocrinol Metab. 2010; 24: 907-914
- Cyclical Cushing syndrome presenting in infancy: an early form of primary pigmented nodular adrenocortical disease, or a new entity?.J Clin Endocrinol Metab. 2004; 89: 3173-3182
- Mutations in regulatory subunit type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes.J Clin Endocrinol Metab. 2009; 94: 2085-2091
- Carney complex.Exp Clin Endocrinol Diabetes. 2019; 127: 156-164
- The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits.J Clin Endocrinol Metab. 2009; 94: 2406-2413
- Cushing syndrome in carney complex: clinical, pathologic, and molecular genetic findings in the 17 affected Mayo Clinic patients.Am J Surg Pathol. 2017; 41: 171-181
- Adrenocortical hyperplasia: a multifaceted disease.Best Pract Res Clin Endocrinol Metab. 2020; 34: 101386
- Genetics of adrenocortical development and tumors.Endocrinol Metab Clin North Am. 2017; 46: 419-433
- Primary bimorphic adrenocortical disease: cause of hypercortisolism in McCune-Albright syndrome.Am J Surg Pathol. 2011; 35: 1311-1326
- Diagnosis and management of primary bilateral macronodular adrenal hyperplasia.Endocr Relat Cancer. 2019; 26: R567-R581
- Molecular mechanisms of ARMC5 mutations in adrenal pathophysiology.Curr Opin Endocr Metab Res. 2019; 8: 104-111
- Incidence of pheochromocytoma and sympathetic paraganglioma in the Netherlands: a nationwide study and systematic review.Eur J Intern Med. 2018; 51: 68-73
- Pheochromocytoma and Paraganglioma in children and adolescents: experience of the French Society of Pediatric Oncology (SFCE).J Endocr Soc. 2020; 4: bvaa039
- Pheochromocytomas and paragangliomas in children: data from the Italian Cooperative Study (TREP).Pediatr Blood Cancer. 2020; 67: e28332
- A single pediatric center experience with 1025 children with hypertension.Acta Paediatr. 1992; 81: 244-246
- Long-term prognosis of patients with pediatric pheochromocytoma.Endocr Relat Cancer. 2014; 21: 17-25
- Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline.J Clin Endocrinol Metab. 2014; 99: 1915-1942
- Plasma methoxytyramine: clinical utility with metanephrines for diagnosis of pheochromocytoma and paraganglioma.Eur J Endocrinol. 2017; 177: 103-113
- Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension.J Hypertens. 2020; 38: 1443-1456
- Current management of pheochromocytoma/paraganglioma: a guide for the practicing clinician in the era of precision medicine.Cancers (Basel). 2019; 11: 1505
- Is supine rest necessary before blood sampling for plasma metanephrines?.Clin Chem. 2007; 53: 352-354
- Phaeochromocytoma - advances through science, collaboration and spreading the word.Nat Rev Endocrinol. 2020; 16: 621-622
- Performance of (68)Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET in detection of pheochromocytoma and paraganglioma: a systematic review and metaanalysis.J Nucl Med. 2019; 60: 369-376
- Emerging treatments for advanced/metastatic pheochromocytoma and paraganglioma.Curr Treat Options Oncol. 2020; 21: 85
- Genomic landscape of pheochromocytoma and paraganglioma.Trends Cancer. 2018; 4: 6-9
- Long-term outcomes of surgical treatment for hereditary pheochromocytoma.J Am Coll Surg. 2013; 216: 280-289
- Pheochromocytoma: a genetic and diagnostic update.Endocr Pract. 2018; 24: 78-90
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